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Finally the degree in which the adverse effects of GLP-agonists on the neonate can be ascribed to maternal malnutrition could be assessed in multiple animal models where the female gets pregnant during either the catabolic stage of GLP-1 agonist exposure or after reaching a stable body weight

This process helps convert fat into usable energy, making it popular among those looking to enhance their fitness performance or support weight management

Therefore, M1 macrophages, which express CD80, CD86, CD40, and MHC-II, contribute to inflammation, cartilage damage, and OA progression

Cell Counting Kit-8 (CCK-8) Assay According to the manufacturer's instructions, the CCK-8 kit (Dojindo, Japan) was used to detect the cell proliferation