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Crosstalk between microglia and astrocytes further contributes to neurodegeneration, as demonstrated by prolonged survival in SOD1 mouse model when this intracellular communication was blocked (Guttenplan et al., 2020b)
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Over-the-counter antacids and H2-blockers (like famotidine) can provide short-term relief, while proton pump inhibitors (PPIs) offer stronger, longer-lasting acid suppression
The mechanism underlying tirzepatide's lipid effects appears multifactorial
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