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Early pharmacokinetic studies suggested that when standard, unprotected glutathione was ingested, it was rapidly cleaved into its constituent amino acids (glutamate, cysteine, and glycine) by digestive enzymes like $\gamma$-glutamyltransferase and harsh stomach acids
All these factors are responsible for the impairment of RBC membrane structure in patients with CKD [260]
Physiological significance of glutathione S-transferases [PMID: 7446736] Laboratory literature summary: Physiological significance of glutathione S-transferases