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Methods: We searched PubMed, Scopus, Cochrane Library, Google Scholar, and Web of Science (ClinicalTrials.gov for unpublished records) from their inception to 5 February 2025, including observational cohort studies and randomized controlled trials

We have previously characterized several notable benefits through this work, including improved left ventricular performance, increased coronary perfusion to the ischemic myocardial region, diminished apoptotic death of ischemic myocytes, and reduced interstitial and perivascular fibrosis within the perfusion-restricted territory

Type 1 mutations can be rescued to a level comparable to that of wild-type p53