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Incretin-based drug development As mentioned above, endogenous GLP-1 has a very short half-life (1-2 minutes) due to its rapid degradation by DPP4, limiting its utility for treatment as a therapeutic
Additionally, most mechanistic studies rely on animal models, raising concerns about translatability to humans due to interspecies differences in GLP-1R distribution and signaling (Drucker, 2022)
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