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While this should logically increase the muscle-building effects, IGF-1 LR3 would also then bypass the internal feedback regulatory pathways, theoretically increasing the risk of negative side effects of excessive growth hormone pathway activity
Similarly, CUR alters the pharmacokinetics of blood pressure medications, potentially compromising their efficacy or safety (80)
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Thus modulation of corticosterone could provide therapeutic strategy to reverse hypoxia induced physiological and pathological disorders
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