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By reducing the water content of the tissue surrounding the cerebral hematoma, enhancing the deformability of red blood cells, improving brain edema, and inhibiting the levels of MMP9 mRNA and AQP4 mRNA in brain tissue, the integrity of the BBB is protected (Zheng et al., 2014
This is the first time the active substance is metabolised in the liver, which is called the first pass metabolism
Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of Stat1 phosphorylation
In contrast, the specific FTH gene knockout of the mouse proximal tubules could exacerbate renal damage in rhabdomyolysis or cisplatin-induced AKI (Zarjou et al., 2013)
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