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consistent physician oversight and lifestyle changes close this gap
McGuire, MD, MHSc , professor of medicine in the division of cardiology, Dallas Heart Ball Chair for Research on Heart Disease in Women and Distinguished Teaching Professor at the University of Texas Southwestern Medical Center, presented results of SOUL at the American College of Cardiology Scientific Session in March, with simultaneous publication in The New England Journal of Medicine
Orforglipron is a once-daily oral GLP-1 by Eli Lilly awaiting an FDA decision for the treatment of adults with obesity or overweight by 2Q 2026
Some patients report that these opposing effects partially cancel each other out, with phentermine providing energy during the day while tirzepatide reduces caloric intake throughout the full 24-hour cycle
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