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It mimics the GLP-1 hormone which is released in the gut as a response to eating
doi: 10.1016/j.cell.2016.11.018 23 BostickJWSchonhoffAMMazmanianSK
Randomized controlled trials before the issue of CVOTs by the FDA in 2008 mainly focused on the efficacy of the blood glucose-lowering effects and a broad spectrum of adverse effects, with limited numbers of cardiovascular adverse events and relatively short follow-up duration
Individuals may find themselves eating in response to these mental cues rather than physiological hunger, leading to excess caloric intake and weight gain over time
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