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The inflammasome, a cytosolic complex comprising innate immunity proteins, activates proinflammatory mediators such as IL-1 and IL-18, with NOD-like receptors (NLRs), particularly NLRP3, playing a crucial role [97]
When free radicals overwhelm the bodys antioxidant defenses, inflammation rises, and metabolic function declines
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However, as you age, these defense mechanisms decrease their activity, causing increased oxidative damage to melanocytes
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