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The human GI tract is estimated to harbor approximately 100 trillion microorganisms, including bacteria, viruses, fungi, and protozoa, collectively encompassing more than 1,000 distinct species (209)
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Naltrexone-bupropion (Contrave) plus semaglutide is occasionally used for non-responders to semaglutide alone
Future research directions include direct comparative trials between various GLP-1 RAs and multi-agonists in MASLD populations to identify optimal therapeutic choices for specific patient subgroups
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