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One influential if controversial explanation is that the increase reflects a socially contagious syndrome: Rapid Onset Gender Dysphoria. ROGD theoryproposes that common cultural beliefs, values, and preoccupations cause some adolescents (especially female adolescents) to attribute their social problems, feelings, and mental health issues to gender dysphoria, according to the article

A recent study found that certain GIPR genetic variants that impair both Gs and beta-arrestin 2 recruitment are linked to lower adiposity 38 , suggesting that GIPR effects on body weight involve complex signalling pathways

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Handle with proper laboratory safety precautions.