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Rose S, Frye RE, Slattery JC, Wynne R, Tippett M, Melnyk S, James SJ (2015) Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines

doi: 10.1007/s11010-009-0358-0

This approach lets you confirm good tolerance before increasing the dose

Using flies and mice, it has been demonstrated that sleep deprivation results in the accumulation of ROS with consequent oxidative stress in the gut, rather than in the brain (Vaccaro et al