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Folate receptor- (FR-) is overexpressed in 5080% of aggressive, poorly differentiated tumors (TNBC, luminal B), with nanomolar-affinity folic acid conjugates enabling clathrin-mediated endocytosis and bypassing P-gp efflux [124]
Furthermore, NAC acts as a direct source of sulfur, helping to replenish the body's sulfate stores required to execute the sulfation pathway of Phase II detoxification
doi: 10.1111/j.1600-0404.1984.tb00851.x 127 HartensteinV.GiangrandeA
"Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients." Eur J Clin Invest
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