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Bursor, J

Complicating the matter, administration of ghrelin still leads to cross-desensitization of dopamine-induced Ca 2+ mobilization, and while ghrelin antagonism also reduces this mobilization, it is possible that concurrent cross-sensitization may also occur, which may possibly carry beyond the timeframe of bioavailability of such an antagonist

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Should marketing authorisation be granted, NICE would subsequently need to evaluate retatrutide for clinical and cost-effectiveness before it could be routinely commissioned on the NHS a process that typically follows initial regulatory approval