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Overall, these data are encouraging that novel weight-loss medications are effective at reducing body weight and they are also effective at improving many of the cardiometabolic complications of obesity including hypertension, Type 2 diabetes and dyslipidemia, among others
The majority (70.1%) of patients discontinued GLP-1 RA therapy within 24 months of initiating therapy
Preclinical studies have examined cagrilintide as a non-selective agonist of the amylin receptors (AMY1R, AMY2R, AMY3R) and the calcitonin receptor, with reported activity in the area postrema and hypothalamus relevant to appetite regulation and satiety signalling
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