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Once-weekly Semaglutide in Adults with Overweight or Obesity New England Journal of Medicine 384(11) 2021PMID: 33567185 NEJM 4 Jastreboff AM, Aronne LJ, Ahmad NN, et al
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More recently, the SUMMIT trial demonstrated that tirzepatide reduced the composite risk of cardiovascular death or worsening heart failure by 38% (HR = 0.62, 95% CI: 0.410.95) in patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 kg/m 2 , 32% of whom also had type 2 diabetes
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