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clinicaltrials.gov retatrutide

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10.1007/s11684-019-0724-6 24 SugaT.KikuchiO.KobayashiM.MatsuiS.Yokota-HashimotoH.WadaE.et al (2019)

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10.1007/BF03179824

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Side Effects Comparison# Retatrutide Side Effects# Phase 2 trial data revealed: Gastrointestinal : Nausea (24-46%), diarrhea (16-26%), vomiting (9-20%), constipation (6-16%) Heart rate : Small mean increase (2-4 bpm) potentially related to glucagon receptor activation Injection site reactions : Mild and transient Hepatic : Transient elevations in liver enzymes observed Discontinuation rate : 6-10% due to adverse events in Phase 2 The glucagon receptor component introduces a unique side effect profile compared to GLP-1-only or GIP/GLP-1 dual agonists

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Low fat dairy is still recommended even though full fat dairy is superior in the majority of studies

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