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The improvement in pharmacokinetics helped prevent the negative gastrointestinal side effects typical of GLP- 1-based selective agonists by reducing maximum drug exposure and reducing reliance on GLP- 1-mediated pharmacology
The researchers, who published their findings in the Annals of the Rheumatic Diseases, added that the result may be mediated by weight loss
Long-term use of GLP-1 receptor agonists may elevate endogenous GLP-2 release, which further reduces antral motility
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