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In luminescence activity profiling, these variants retained comparable activity on the procaspase-1 (residues 304320) substrate used for evolution as X(PC), but showed no cleavage of IL-1 (residues 529) or ORC1 (residues 691707
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5,6, 7 Additionally, there is suppression of other melanocyte metabolic processes decreasing melanin formation via selective damage to melanosomes and melanocytes through production of reactive oxygen radicals
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