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After 28 days, potency may decline even under ideal storage conditions

DPP-4 inhibitors may be preferred for: Patients unable or unwilling to use injectable therapies Elderly individuals where the lower hypoglycaemia risk is particularly valuable Those at high risk of hypoglycaemia from other medications Patients requiring modest glycaemic improvements Individuals where weight neutrality is acceptable or desired Important cautions and contraindications: Do not combine a GLP-1 receptor agonist with a DPP-4 inhibitor

Transdermal microneedle patches as a promising drug delivery strategy

Combination protocols: Because the two compounds act on entirely separate axes, some clinicians use both simultaneously