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In addition, leptin supplementation combined with long-term antagonism of the ghrelin receptor using palm-LEAP2(114) exerts a beneficial and synergistic effect on rectal temperature and BAT uptake of glucose, the primary fuel source for thermogenesis, in leptin-deficient obese ob/ob mice [139]

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However, GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists represent different pharmacological classes with distinct safety profiles