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Immunology 53:29197.[PubMed], [Web of Science ] , [Google Scholar]) postulate that this biphasic response is due to low doses of CGN stimulating a population of suppressor macrophages that actively suppress T lymphocyte proliferation, while higher doses abolish suppressor activity via cytotoxicity
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It typically peaks between days 310 and resolves within 24 weeks as your gastrointestinal tract adapts to altered signaling
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