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Greenberg, B
GLP-1R activation has a significant effect on glycemic control in patients with T2DM through a variety of mechanisms, including stimulation of insulin secretion, inhibition of glucagon secretion, protection of -cells from apoptosis, slowing gastric emptying and increasing satiety ( 2 GLP-1R GLP-1R is a G protein-coupled receptor (Wu et al., 2020) (Figure 1A)
Finerenone, a selective non-steroidal MRA, has led this advancement by targeting aldosterone-mediated inflammatory and fibrotic signaling pathwayskey drivers of DKD progression
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