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Semaglutide works by mimicking a naturally occurring GLP-1 hormone involved in appetite regulation and metabolic function
Previous studies have shown that higher glucose metabolism is associated with higher BOLD signal amplitudes, and that higher degrees of brain functional connectivity are associated with nonlinear increases in metabolism in healthy subjects by comparing PET and rs-fMRI
Common GLP-1 agonists include: Semaglutide (Ozempic, Wegovy) Liraglutide (Victoza, Saxenda) Dulaglutide (Trulicity) Tirzepatide (Zepbound) While initially used for diabetes management, studies showed that GLP-1 agonists also contribute significantly to weight loss, leading to their approval for obesity treatment as well
Tirzepatide is a dual GIP and GLP-1 receptor agonist , meaning it activates receptors responsive to two different incretin hormones: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
