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437 In cisplatin-sensitive oral squamous cell carcinoma, the autophagy-associated protein LC3B-II was found to be enriched in EVs, potentially modulating drug sensitivity in neighboring cells via miRNA transfer, highlighting its promise as a noninvasive biomarker for cisplatin resistance

Goldstein, A.L

While it has not been conclusively established whether this dysfunction is a cause or consequence of the pathological processes, growing evidence suggests that reduced proteasomal activity may contribute to the accumulation of toxic protein aggregates and the progression of neurodegeneration