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10.1056/NEJMoa2301972 40 JantrapiromS.NimlamoolW.ChattipakornN.ChattipakornS.TemviriyanukulP.InthachatW.et al (2020)
Purpose-built for physicians Oral GLP-1 reduces body weight, HbA1c for adults with obesity plus type 2 diabetes Key takeaways: All doses of orforglipron conferred greater decreases in weight and HbA1c compared with placebo
Safety and Clinical Management Safety trials of GLP-1 RAs, including liraglutide, tirzepatide, and semaglutide (oral or subcutaneous), indicate that the most common adverse events (AEs) of treatment are mild to moderate gastrointestinal including nausea, vomiting, diarrhea, constipation, dyspepsia, and decreased appetite
- Review ingredient labels carefully: Ensure the supplement clearly states the active ingredients, their dosages, and the percentage of recommended daily intake (RDI) provided
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