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That said, there are some important caveats: Lack of human clinical trials: Rodent models represent the bulk of the available data

The free tripeptide GHK has a high affinity for divalent copper ions and exists in human plasma predominantly as the GHK-Cu complex

Those who with neuropathy present with a warm, swollen, red foot requires a thorough work up for possible charcot neuroarthropathy, nonweight bearing and urgent referral to a foot care specialist to prevent foot deformities and instability leading to ulcerations and amputations

Furthermore, disturbances of the ALDH-catalyzed detoxification of DOPAL, a reactive DA metabolite, can be pathogenic