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MBX 4291, dual GLP-1/GIP co-agonist prodrug designed for potential once-monthly dosing and improved tolerability in obesity Recent Highlights: In June 2026, MBX Biosciences announced data that demonstrated sustained benefit of its once-weekly Canvuparatide as a potential PTH replacement therapy in chronic hypoparathyroidism
The tripeptide sequence glycyl-L-histidyl-L-lysine wraps around a copper ion, creating a structure with remarkable stability when handled correctly and surprising fragility when handled wrong
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doi: 10.1111/tra.12707, 148
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