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Rapid weight reduction may trigger body image concerns, changes in self-identity, or shifts in interpersonal relationships
To maximise the cardiovascular benefits of GLP-1 RAs at a population level, strategies can be used to improve tolerability, such as patient counselling, gradual dose escalation and the use of long-acting formulations [27]
[12] [1] As an IMP, its storage and handling are governed by Good Clinical Practice (GCP) guidelines, EU/UK GMP Annex 13 (Investigational Medicinal Products), and the specific trial protocol not by a publicly available regulatory document
These medications can be highly effective for weight loss and metabolic health, but they also come with side effects, high costs, and the need for lifestyle changes to maintain results
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