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We hypothesise that a few mechanisms may have contributed to the observed cardioprotective effects of GLP-1RAs in our study: (1) this class of glucose-lowering drugs induces weight loss, which has a positive impact and results in a better cardioprotective effect
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The comparison standard Because retatrutide already has strong activity across three metabolic receptors, any added compound should be judged against a simple question: what new pathway does it add, and is there human evidence that the added pathway improves outcomes with retatrutide
While these findings provide mechanistic plausibility for L-carnitine's effects on IR, most evidence derives from animal or cellular models, with limited human histological validation or pathway-intervention studies
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