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Growth experiments on D-malate for the mdh mutant revealed reduced growth (instead of abolished growth) which might be attributed to a theoretical malate racemase activity of A
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The supernatant was aspirated and the cell pellet was suspended in supplemented DMEM media for further experiments
Meanwhile, a semiconductor polymer nanoscale PROTAC (SPNFeP) formed by nano-precipitation through sonodynamic semiconductor polymer, ferroptosis inducers, and newly synthesized proteolysis-targeting chimera (PROTAC) molecules, can deliver activated PROTAC molecules to tumor sites to degrade nicotinamide phosphoribosyltransferase (NAMPT) thereby inhibiting the infiltration of tumor MDSCs, promoting anti-tumor immunity and suppressing tumor growth (136)
