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The rationale for caution relates to redundancy: both drug classes ultimately increase GLP-1 signaling at the pancreatic beta cell
Prominent features include epithelial barrier dysfunction, delayed or accelerated gastrointestinal transit due to abnormal function of smooth muscles, dysfunctional enteric nervous system and/or immunity, gut microbial dysbiosis, bile acid malabsorption, and alterations in the gut-brain axis (812)
Source: Gorgojo et al, published in the journal, Journal of Clinical Medicine in 2023
En contraste, algunos pacientes que utilizan estos medicamentos exclusivamente para prdida de peso pueden tener mayor flexibilidad, aunque la obesidad tambin se considera una enfermedad crnica que tpicamente requiere manejo a largo plazo
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