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Unimolecular dual incretins: GLP-1/GIP receptor agonists in metabolic disease models. Trends Pharmacol Sci

5.4.2 Effects on liver Despite the lack of expression of GIPR (41, 191) and GLP-1R (192, 193) in hepatocytes, both GIP and GLP-1 have indirect effects on hepatic lipid and glucose metabolism (194)

Albright at Cargill summarized the issue directly: Taste is always going to be the beginning and the end. The opportunity emerging from GLP-1 is therefore to identify the consumers precise need, formulate an appropriate experience, and deliver a product they will choose repeatedly.

Additionally, combining Wellbutrin with alcohol can increase the risk of neuropsychiatric side effects and seizures