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Glucagon-Like Peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat -Cells by a protein kinase A-mediated mechanism
As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA), tirzepatide produces synergistic effects like increased insulin production and release, which gives it an edge over strict GLP-1 receptor agonist such as semaglutide (Ozempic)
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