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However, so far across studies with GLP1R agonists , cardiovascular measurements such as blood pressure have seen improvements in general, with no significant increases in adverse cardiovascular effects seen in patients even after 2 years (In fact, decreases were seen), suggesting that the cardiovascular benefits of decreased body weight may overcome any potential harm that increases in heart rate by GLP1R agonists may cause
Muscle mass decreases at 3 to 8% per decade after 30
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In men, weight loss has been associated with improved sperm parameters, including sperm count, motility, and morphology, alongside beneficial changes in testosterone levels
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