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As more people turn to these weight loss solutions, it's important to understand not only how to use them effectively but also to stay alert to even the rare side effects that could arise
Q: What were the Phase 3 SURMOUNT-1 results
In HFrEF, an issue remains that because GLP-1 RAs have been shown to modestly increase heart rate (2-3 beats per minute) owing to their chronotropic effects (see Mechanisms) (Sun et al., 2015), GLP-1 RA treatment in HFrEF may be problematic considering that, in line with the use of beta-blockers to ameliorate HFrEF (11, 12), heart rate elevations may result in a worse outcome (Rossignol et al., 2015) and may therefore not benefit from the weight-reducing effect of GLP-1 RAs
Diabetes Care 35 , e58 (2012)
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