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A multifunctional poly(amino acid) nanomedicine (PM-DPA/R848) has been developed that encapsulates the TLR7/8 agonist resiquimod (R848) within a nanocarrier composed of poly(L-methionine) and alendronate-functionalized DSPE-PEG ( Calcium carbonate (CaCO3)-based nanosystems have been engineered to simultaneously neutralize the acidic TME and reprogram TAM polarization
3-Adrenergic Receptor Modulation Both hGH and AOD9604 increase 3-adrenergic receptor (3-AR) expression in adipose tissue importantly, restoring repressed 3-AR RNA levels in obese mice to levels comparable with those in lean mice
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Available from: Carris NW, Wallace S, DuCoin CG, Mhaskar R, Stern M, Bunnell B
