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In the vascular system, oxidative stress in diabetes activates ROS-mediated Akt and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascades, promoting autophagy in endothelial cells while downregulating HDAC6 expression, which impairs cell migration and adhesion
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Cagrilintide represents the breakthrough next-generation amylin agonist with weekly dosing, 10-12% monotherapy weight loss, and proven synergy with GLP-1 agonists when combined
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