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LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose

The primary endpoint - MASH improvement absent fibrosis progression - was observed in 47%, 62%, and 43% of the 2.4, 4.8, and vs

This escalation pattern is consistent with other GLP-1 receptor agonists and should be considered when designing preclinical study protocols that aim to replicate clinical pharmacokinetics

Using human liver microsomes, it was also recently reported that sulforaphane metabolites (0-200 M) had little-to-no effect on the activities of CYP1A2, CYP2B6, CYP2D6, and CYP3A4 (23)