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Owing to its high concentration in the cell (~10 3 M) 1 , the GSH/GSSG pair acts as the main intracellular redox buffer, plays a key role in the detoxification of reactive oxygen species (ROS), and participates in redox signalling 2

Differing compartments of intracellular glutathione have differing levels of [PMID: 17097824] Laboratory literature summary: Differing compartments of intracellular glutathione have differing levels of glutathione in cystic fibrosis

Biological Implications of the Nucleophilic Addition of Glutathione to Quinoid Compounds 26

This stark contrast highlights the importance of addressing adherence challenges