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Symptoms include difficulty breathing, facial or throat swelling, rapid pulse, severe dizziness, or widespread rash
However, in certain cases, they may interfere with the peptides ability to interact with its target or disrupt bioactive conformation, significantly reducing its activity 44,45
Manik and Singh, 2022)
Novel nucleic acid nanocomplexes, such as CpG-STAT3 siRNA conjugates (NCT04995536), were evaluated for their ability to silence oncogenic pathways and stimulate immune responses in relapsed B-cell non-Hodgkin lymphoma (NHL), although the study was withdrawn before completion
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