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ITT, insulin tolerance test

Absolute contraindications: Personal or family history of medullary thyroid carcinoma (MTC), Multiple Endocrine Neoplasia syndrome type 2 (MEN2), known hypersensitivity to semaglutide or any excipient Relative contraindications: History of pancreatitis, severe gastrointestinal disease (gastroparesis, inflammatory bowel disease), current pregnancy or planned pregnancy within 2 months, history of suicidal ideation or major depressive disorder (monitor closely) Use with caution: Patients on insulin or sulfonylureas (hypoglycemia risk), patients with diabetic retinopathy (risk of transient worsening), patients with renal impairment (adjust monitoring) Pre-Treatment Workup Thorough semaglutide training for physicians includes a standardized pre-treatment assessment protocol

Tirzepatide users often report that diarrhea resolves faster, typically within the first two to three weeks at each new dose level

When used for more than 12 weeks, Wegovy can lead to major weight loss