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One impact of the plant (main constituents are harmine and harmaline ) is that it increases GLP-1 in the hippocampus.[ref] Lithium: Lithium carbonate seems to suppress food intake (in some people) by activating GLP-1
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However, it has been shown that a network pharmacology-based approach can reveal therapeutic targets
In a more recent review from 2024 comprising patients with bipolar disorder from North America, Europe and Australia, antidepressants were prescribed cross-sectionally for 38%, being among the most prescribed medications [11]
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