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SURMOUNT-5, published in the New England Journal of Medicine, directly compared the maximum tolerated doses of tirzepatide and semaglutide in the same patient population
Food and Drug administration
casei Zhang LDH: lactate dehydrogenase LDHA: lactate dehydrogenase A LDLR: low-density lipoprotein receptor LPS: lipopolysaccharide LTA: lipoteichoic acid LXR: liver X receptor MAMPs: microbial-associated molecular patterns MAPK: mitogen-activated protein kinase MCT4: monocarboxylate transporter 4 MDA: malondialdehyde MDMs: monocyte-derived macrophages miRNA: microRNA MR: mannose receptor NFD: normal fat diet NF-B: nuclear factor B NLRs: NOD-like receptors NO: nitric oxide OCR: oxygen consumption rate OXPHOS: oxidative phosphorylation PBMCs: peripheral blood mononuclear cells PCNA: Proliferating cell nuclear antigen PD: peritoneal dialysis Pdha1: pyruvate dehydrogenase 1 Pdhx: pyruvate dehydrogenase X Pdk2: pyruvate dehydrogenase kinases 2 Pdk4: pyruvate dehydrogenase kinases 4 PE: polyethylene PFK1: phosphofructokinase 1 PGN: peptidoglycan PKM2: pyruvate kinase M2 PMs: peritoneal macrophages PPAR-: peroxisome proliferator-activated receptor- PPAR: Peroxisome proliferator activator receptor delta PPP: pentose phosphate pathway PRRs: pattern recognition receptors RCT: reverse cholesterol transport RIG-I: retinoic acid-induced gene-1 RIPK2: serine/threonine protein kinase 2 ROS: reactive oxygen species RSV: respiratory syncytial virus S
Aging Cell 21 , e13589 (2022)
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