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GHK (glycyl-L-histidyl-L-lysine) is a human plasma copper-binding peptide that declines during aging
TrxR, thioredoxin reductase
Nuclear oxidative stress affects TAO through several mechanisms: DNA damage: ROS directly damage DNA in orbital fibroblasts of TAO patients, causing strand breaks, base modifications, and oxidative lesions that disrupt gene expression and DNA repair mechanisms (70)
Cao HY, Lian JN, Lin ZS, Zhu ZW, Wang H,Wang HY
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