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Description

These data support the calculation of the Maximum Recommended Starting Dose (MRSD) the starting dose for the first administration in humans, derived from preclinical data and converted to a human equivalent dose using internationally agreed methods

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A systematic review and meta-analysis of overweight and obese patients showed modest weight loss of 510% led to reduction in LDL-C of 0.20 mmol/dL (8 mg/dL) and triglycerides by 0.13 mmol (12 mg/dL) as well as substantial reduction in blood pressure, fasting plasma glucose, and hemoglobin A1c [26]

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