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Intensified multifactorial intervention in type 2 diabetics with microalbuminuria leads to long-term renal benefits

GIP receptor agonism further augments insulin release and may influence fat metabolism, though the precise contribution of GIP receptor activation to clinical outcomes in humans remains an area of active investigation

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This is consistent with the previous findings that hypoxia-response genes were upregulated in the islets of diabetic, but not prediabetic, db/db mice in an inverse relationship with unfolded protein response gene expression 28,33