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In response to lipopolysaccharide stimulation, exendin-4 reduced the expression of IL-1 and TNF- in these cells (85)

Once ROS overwhelms the antioxidant activity of the cell, oxidative stress occurs ( in-vitro study found that berberine protected NSC34 cells from H 2 O 2 -induced cytotoxicity by reducing ROS production, restoring glutathione, and superoxide dismutase activity, and activating the production of antioxidant proteins nuclear factor erythroid 2-related factor-2 (Nrf2) and HO-1 ( Studies have found that berberine has an antidepressant effect (Figure 1)