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Inflammatory processes are also involved in BBB leakage and disruption in status epilepticus

When cells are exposed to oxidative and/or electrophilic stress, KEAP1 thiol residues are directly modified, which inactivates the ubiquitin E3 ligase activity of KEAP1-CUL3 complex, leading to stabilization of NRF2

Hemodiafiltration Hemodiafiltration (HDF) has been evaluated prospectively in a few RCTs with conflicting results

In people with HF, this is accompanied by a metabolic shift toward water and energy conservation [33], resembling estivation, a physiological adaptation observed in animals during prolonged nutrient and water scarcity [34]